Publications

2025

Rogers JT, Tsurumi A, Arai K, Wang C, Cahill CM. A hemochromatosis allele that protects against Alzheimer’s disease injury: A role for H-ferritin. J Alzheimers Dis. 2025 Dec 22:13872877251404974. Publisher’s Version

Wang Y, Wang Y, Xu Y, Yang H, Huang Y, Cheng H, Wang C. Development of a Novel PET Radioligand for Imaging the Adenosine A2A Receptor in the Brain. ACS Chem Neurosci. 2025 Dec 22. doi: 10.1021/acschemneuro.5c00827. Publisher’s Version

Yang H, Wang Y, Xu Y, Wang C. CX3CR1: a potential microglia-specific PET imaging target in Alzheimer’s and Parkinson’s diseases. Front Pharmacol. 2025 Dec 4:16:1678159. Publisher’s Version

Cheng H, Bai L, Liu X, Pan X, Wang Y, Wang Y, Zhang F, Xu X, Li P, Wang C, Song S. Linker-Driven Breakthrough: Design of a Novel Linker for Enhanced Theranostic Performance of FAPI Trimer. J Med Chem. 2025 Dec 25;68(24):25981-25993. Publisher’s Version

Li H, Qin Z, Zhou Y, Meng H, Xie W, Yao P, Yang X, Cai H, Li L, Wang C, Wu X, Bai P. Development and Preclinical Evaluation of Novel F-18-Labeled Dihydropyrazole RIPK1 PET Tracers for Neuroinflammation Imaging. J Med Chem. 2025 Dec 11;68(23):25590-25606. Publisher’s Version

Wang Y, Wang Y, Zhang W, Xu Y, Narayan NS, Cheng H, Yang H, Huang Y, Zhang C, Wang C. Development of a Novel PET Radioligand Targeting PKM2 for Brain Imaging and Alzheimer’s Disease Characterization. J Med Chem. 2025 Dec 11;68(23):25456-25468. Publisher’s Version

Yoo CH, Xu Y, Bagdasarian FA, Lin YS, Wang C, Wey HY. Cannabinoid 1 receptor occupancy and neurovascular responses induced by agonist, antagonist/inverse-agonist, and potential modulator in non-human primate brains: PET/fMRI study. J Cereb Blood Flow Metab. 2025 Nov 3:271678X251389042. Publisher’s Version

Zhou IY, Zhang C, Sojoodi M, Rotile NJ, Lan Y, Barrett SC, Wang C, Schaefer CJ, Kossen K, Seiwert SD, Tanabe KK, Caravan P. 18F-FPP-RGD2 PET Imaging for Interrogating Target Engagement and Antifibrotic Activity of an Integrin Antagonist in a Mouse Model of Metabolic Dysfunction-Associated Steatohepatitis. J Nucl Med. 2025 Nov 3;66(11):1795-1802. Publisher’s Version

Goodheart A, Yoo CH, Fassini A, Dagnew T, Ye R, Striar R, Quan M, Rattray A, Meyer T, Peterec E, Lee H, Fiedler S, Hooker J, Wey HY, Wang C, Gomperts S. Imaging brain class I histone deacetylase changes in the Lewy body dementias and Parkinson’s disease. Res Sq[Preprint]. 2025 Aug 11:rs.3.rs-6647341.

Liu Y, Sun Y, Zhao P, Liu Z, Wang Y, Wang Y, Zhao R, Wang C, Wang S.Near-Infrared Fluorescent Probe for the Early Diagnosis of Alzheimer’s Disease. Med Res Rev. 2026 Jan;46(1):5-39. Publisher’s Version

Jana S, Ahmadi P, Yan X, Bai P, Liow JS, Jenson AE, Pamie-George MT, Zoghbi SS, Wu S, Wang C, Innis RB, Pike VW, Telu S.Syntheses and preclinical evaluations of 11C-labeled radioligands for imaging brain orexin-1 and orexin-2 receptors with positron emission tomography. RSC Med Chem. 2025 Jun 20. doi: 10.1039/d5md00382b. Publisher’s Version

Lee SJ, Wang C, Hooker J. Microglia matters: visualizing the immune battle in Parkinson’s disease. J Clin Invest. 2025 Jun 16;135(12):e192919. Publisher’s Version

Cheng H, Wang Y, Wang Y, Dagnew TM, Siewko A, Varela BL, Ma P, Hallisey MR, Cheng A, Wang C, Xu Y. Synthesis and characterization of a new Carbon-11 labeled positron emission tomography radiotracer for RIPK1 neuroimaging. Comput Biol Med. 2025 Jun;192(Pt B):110324. Publisher’s Version

Bai P, Gomm A, Yoo CH, Mondal P, Lobo FM, Meng H, Zhou Y, Xie W, Wey HY, Tanzi RE, Zhang C, Wang C, Lan Y. Development of Carbon-11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma-1 Receptor Imaging. Adv Sci (Weinh). 2025 Jun;12(21):e2414827. Publisher’s Version

Guo S, Yang L, Ding W, Dagnew TM, Gao Y, Wang W, Wang P, Huang S, Ran C, Wang C, Shen L, Chen Q, Akeju O, Shen S. Hippocampal Neural Dynamics and Postoperative Delirium-like Behavior in Aged Mice. Anesthesiology. 2025 Sep 1;143(3):625-640. Publisher’s Version

Wang Y, Wang Y, Xu Y, Cheng H, Dagnew TM, Kang L, Tocci D, Shen IZ, Zhang C, Wang C. Design and Development of a Novel BET Protein-Targeted PET Imaging Probe for In Vivo Characterization of Alzheimer’s Disease Pathophysiology. J Med Chem. 2025 Apr 10;68(7):7605-7614. Publisher’s Version

Bai P, Mondal P, Liu Y, Gomm A, Suen C, Yang L, Zhu B, Sun H, Ran C, Shen S, Tanzi RE, Zhang C, Wang C. HDAC11 displays neuropathological alterations and offers as a novel drug target for Alzheimer’s disease. Alzheimers Dement. 2025 Mar;21(3):e14616. Publisher’s Version

Xu Y, Xu Y, Bagdasarian FA, Dagnew TM, Cheng H, Wang Y, Wang Y, Kang L, Wey HY, Zhang C, Zhang S, Wang C. Characterization of a novel PET radioligand for mitochondrial complex I in nonhuman primate. Nucl Med Biol. 2025 Mar-Apr:142-143:108993. Publisher’s Version

2024

Wang Y, Wang Y, Xu Y, Cheng H, Dagnew TM, Kang L, Tocci D, Shen IZ, Zhang C, Wang C. Development of a PET Probe Targeting Bromodomain and Extra-Terminal Proteins for In Vitro and In Vivo Visualization. Pharmaceuticals (Basel). 2024 Dec 11;17(12):1670. Publisher’s Version

Yang L, Gomm A, Bai P, Ding W, Tanzi RE, Wang C, Shen S, Zhang C. The Effect of Pexidartinib on Neuropathic Pain via Influences on Microglia and Neuroinflammation in Mice. Anesth Analg. 2024, 141(1):199-209. Publisher’s Version

Zhou Y, Li C, Wu R, Yin H, Liu G, Meng H, Xie W, Birar VC, Wang C, Wu X, Bai P. Molecular Imaging Reveals Antineuroinflammatory Effects of HDAC6 Inhibition in Stroke Models. Mol Pharm. 2024 Dec 2;21(12):6433-6443. Publisher’s Version

Wang Y, Wang Y, Xu Y, Kang L, Tocci D, Wang C. The Development and Evaluation of a Novel Highly Selective PET Radiotracer for Targeting BET BD1. Pharmaceuticals (Basel). 2024 Sep 27;17(10):1289. Publisher’s Version

Zhong X, Wu X, Zhou Y, Wu R, Yang J, Yin H, Meng H, Xie W, Liu G, Wang C, Bai P, Zhang W. PET imaging assist investigation of HDAC6 expression change in MDD and evaluating antidepressant efficacy of a newly developed HDAC6 inhibitor. Eur J Med Chem. 2024 Sep 26:280:116908. Publisher’s Version

Biby S, Mondal P, Xu Y, Gomm A, Kaur B, Namme JN, Wang C, Tanzi RE, Zhang S, Zhang C. Functional Characterization of an Arylsulfonamide-Based Small-Molecule Inhibitor of the NLRP3 Inflammasome. ACS Chem Neurosci. 2024 Oct 2;15(19):3576-3586. Publisher’s Version

Luo T, Zhou Y, Wu R, Yin H, Xie W, Meng H, Zhao C, Wang Y, Wang Y, Kang L, Wu X, Wang C, Bai P. Design, synthesis, and preclinical evaluation of 11C/18F-labeled inhibitors for RIPK1 PET imaging. Eur J Med Chem. 2024 Sep 6:279:116851. Publisher’s Version

Wang Y, Wang Y, Xu Y, Tocci D, Wang C. Development and Evaluation of [11C]I-58: A Novel PET Radiotracer Targeting BRD4 BD2 for Advanced Epigenetic Imaging. ACS Omega. 2024 Aug 12;9(34):36177-36184. Publisher’s Version

Dagnew TM, Tseng CJ, Yoo CH, Makary MM, Goodheart AE, Striar R, Meyer TN, Rattray AK, Kang L, Wolf KA, Fiedler SA, Tocci D, Shapiro H, Provost S, Sultana E, Liu Y, Ding W, Chen P, Kubicki M, Shen S, Catana C, Zürcher NR, Wey HY, Hooker JM, Weiss RD, Wang C. Toward AI-driven neuroepigenetic imaging biomarker for alcohol use disorder: A proof-of-concept study. iScience. 2024 May 31;27(7):110159. Publisher’s Version

Bai P, Lan Y, Liu Y, Mondal P, Gomm A, Xu Y, Wang Y, Wang Y, Kang L, Pan L, Bagdasarian FA, Hallisey M, Lobo F, Varela B, Choi SH, Gomperts SN, Wey HY, Shen S, Tanzi RE, Wang C, Zhang C. Development of a New Positron Emission Tomography Imaging Radioligand Targeting RIPK1 in the Brain and Characterization in Alzheimer’s Disease. Adv Sci (Weinh). 2024 Aug;11(32):e2309021. Publisher’s Version

Bai P, Bagdasarian FA, Xu Y, Wang Y, Wang Y, Gomm A, Zhou Y, Wu R, Wey HY, Tanzi RE, Zhang C, Lan Y, Wang C. Molecular Imaging of Alzheimer’s Disease-Related Sigma-1 Receptor in the Brain via a Novel Ru-Mediated Aromatic 18F-deoxyfluorination Probe. J Med Chem. 2024 Apr 25;67(8):6207-6217. Publisher’s Version

Luo T, Sang N, Liu Y, Zhou Y, Wu R, Bagdasarian FA, Wey HY, Lang J, Wang C, Bai P. Synthesis and preclinical evaluation of 11C-labeled 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine radioligands for RIPK1 positron emission tomography imaging. Bioorg Chem. 2024 May:146:107279. Publisher’s Version

Wang Y, Liu Y, Wang Y, Bai P, Hallisey MR, Varela BL, Siewko A, Wang C, Xu Y. Development and Characterization of a Novel Carbon-11 Labeled Positron Emission Tomography Radiotracer for Neuroimaging of Sirtuin 1 with Benzoxazine-Based Compounds. Drug Des Devel Ther. 2024 Mar 15:18:819-827. Publisher’s Version

Wang Y, Wang Y, Liu Y, Cheng H, Dagnew TM, Xu Y, Wang C. Synthesis and Characterization of a New Carbon-11 Labeled Positron Emission Tomography Radiotracer for Orexin 2 Receptors Neuroimaging. Drug Des Devel Ther. 2024 Jan 31:18:215-222. Publisher’s Version

Xu Y, Xu Y, Biby S, Kaur B, Liu Y, Bagdasarian FA, Wey HY, Tanzi R, Zhang C, Wang C, Zhang S. Design and Discovery of Novel NLRP3 Inhibitors and PET Imaging Radiotracers Based on a 1,2,3-Triazole-Bearing Scaffold. J Med Chem. 2024 Jan 11;67(1):555-571. Publisher’s Version

Zhang J, Wickizer C, Ding W, Van R, Yang L, Zhu B, Yang J, Wang Y, Wang Y, Xu Y, Zhang C, Shen S, Wang C, Shao Y, Ran C. In vivo three-dimensional brain imaging with chemiluminescence probes in Alzheimer’s disease models. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2310131120. Publisher’s Version

Mondal P, Bai P, Gomm A, Bakiasi G, Lin CJ, Wang Y, Choi SH, Tanzi RE, Wang C, Zhang. Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer’s Disease Neuropathology. Adv Sci (Weinh). 2024, 11(1):e2304545. Publisher’s Version

2023

Bai P, Liu Y, Yang L, Ding W, Mondal P, Sang N, Liu G, Lu X, Ho TT, Zhou Y, Wu R, Birar VC, Wilks MQ, Tanzi RE, Lin H, Zhang C, Li W, Shen S, Wang C. Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice. J Med Chem. 2023, 14;66(23):16075-16090. Publisher’s Version

Chen Z, Yang X, Chen Z, Li M, Wang W, Yang R, Wang Z, Ma Y, Xu Y, Ao S, Liang L, Cai C, Wang C, Deng T, Gu D, Zhou H, Zeng G. A new histone deacetylase inhibitor remodels the tumor microenvironment by deletion of polymorphonuclear myeloid-derived suppressor cells and sensitizes prostate cancer to immunotherapy. BMC Med. 2023 Oct 25;21(1):402. Publisher’s Version

Ding W, Yang L, Shi E, Kim B, Low S, Hu K, Gao L, Chen P, Ding W, Borsook D, Luo A, Choi JH, Wang C, Akeju O, Yang J, Ran C, Schreiber KL, Mao J, Chen Q, Feng G, Shen S. The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption. Nat Commun. 2023 Oct 25;14(1):6696. Publisher’s Version

Lu J, Liang F, Bai P, Liu C, Xu M, Sun Z, Tian W, Dong Y, Zhang Y, Quan Q, Khatri A, Shen Y, Marcantonio E, Crosby G, Culley DJ, Wang C, Yang G, Xie Z. Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice. Alzheimers Dement. 2023 Sep;19(9):4110-4126. Publisher’s Version

Ding W, Yang L, Chen Q, Hu K, Liu Y, Bao E, Wang C, Mao J, Shen S. Foramen lacerum impingement of trigeminal nerve root as a rodent model for trigeminal neuralgia. JCI Insight. 2023 Jun 8;8(11):e168046.Publisher’s Version

Ding W, Fischer L, Chen Q, Li Z, Yang L, You Z, Hu K, Wu X, Zhou X, Chao W, Hu P, Dagnew TM, Dubreuil DM, Wang S, Xia S, Bao C, Zhu S, Chen L, Wang C, Wainger B, Jin P, Mao J, Feng G, Harnett MT, Shen S. Highly synchronized cortical circuit dynamics mediate spontaneous pain in mice. J Clin Invest. 2023;133(5):e166408. Publisher’s Version

Liu G, Mondal P, Sang N, Li Z, Ding W, Yang L, Liu Y, Birar VC, Gomm A, Tanzi RE, Zhang C, Shen S, Wang C, Lu X, Bai P. Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors. Eur J Med Chem. 2023;254:115327. Publisher’s Version

Liu Y, Chen Z, Wang Y, Hallisey MR, Varela BL, Siewko A, Tocci D, Wang C, Xu Y. 1Noninvasive Positron Emission Tomography Imaging of SIRT1 in a Model of Early-Stage Alcoholic Liver Disease. Mol Pharm., 2023, 20(4):1990-1995. Publisher’s Version

2022

Yuan G, Dhaynaut M, Lan Y, Guehl NJ, Huynh D, Iyengar SM, Afshar S, Jain MK, Pickett JE, Kang HJ, Wang H, Moon SH, Ondrechen MJ, Wang C, Shoup TM, El Fakhri G, Normandin MD, Brownell AL. “Synthesis and Characterization of 5-(2-Fluoro-4-[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2.” J Med Chem. 2022, 65(3):2593-2609. Publisher’s Version

Zhang S, Bai P, Lei D, Liang Y, Zhen S, Bakiasi G, Pang H, Choi SH, Wang C, Tanzi RE, Zhang C. “Degradation and Inhibition of Epigenetic Regulatory Protein BRD4 Exacerbate Alzheimer’s Disease-Related Neuropathology in Cell Models.” J Biol Chem. 2022, 3:101794. Publisher’s Version

Xu Y, Liu Y, Striar R, Langan A, Kate Rattray A, Afshar S, Wang C. Preliminary studies of an imidazole-based alcohol derivative for imaging of Heme oxygenase 1. Bioorg Med Chem Lett. 2022, 64:128674. Publisher’s Version

Bai P, Liu Y, Xu Y, Striar R, Yuan G, Afshar S, Langan AG, Rattray AK, Wang C. Synthesis and characterization of a new Positron emission tomography probe for orexin 2 receptors neuroimaging. Bioorg Chem. 2022, 123:105779. Publisher’s Version

Zhu G, Bai P, Wang K, Mi J, Yang J, Hu J, Ban Y, Xu R, Chen R, Wang C, Tang L, Sang Z. Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer’s disease. J Enzyme Inhib Med Chem. 2022, 37(1):1375-1388. Publisher’s Version

Chen Z, Yang R, Xu Y, Liang L; Ao S, Wang Z, Bai P, Gu D, Duan X, Liu Y, Zhong W, Xu P, Deng T, Zeng G, Wang C. PET imaging of Bromodomain and Extra-Terminal domain inhibitor for the non-invasive assessment of metabolic changes in liver and brain of early-stage alcoholic liver disease. Molecular Pharmaceutics, 2022, 2022, 19, 7, 2335–2342. Publisher’s Version

Bai P, Mondalb P, Bagdasariana FA, Rania N, Liu Y, Gomm A, Tocci DR, Choi SH, Wey HY, Tanzi RE, Zhang C, Wang C. Development of a Potential PET Probe for HDAC6 Imaging in Alzheimer’s Disease. Acta Pharmaceutica Sinica B. 2022, 12 (10), 3891-3904. Publisher’s Version

Xu Y, Blevins H, Xu Y, Guo C, Wang XY, Wang C, Zhang S. Development of sulfonamide-based NLRP3 inhibitors: Further modifications and optimization through structure-activity relationship studies. European Journal of Medicinal Chemistry. 2022, 238, 114468. Publisher’s Version

Liang Y, Lee DYW, Zhen S, Sun H, Zhu B, Liu J, Lei D, Lin CJ, Zhang S, Jacques NA, Quinti L, Ran C, Wang C, Griciuc A, Choi SH, Dai RH, Efferth T, Tanzi RE, Zhang C. Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer’s disease. Phytomedicine. 2022, 104, 154158. Publisher’s Version

Zhu B, Yang J, Van R, Yang F, Yu Y, Yu A, Ran K, Yin K, Liang Y, Shen X, Yin W, Choi SH, Lu Y, Wang C, Shao Y, Shi L, Tanzi RE, Zhang C, Cheng Y, Zhang Z and Ran C. Epitope alteration by small molecules and applications in drug discovery. Chemical Science. 2022, 13, 8104-8116. Publisher’s Version

Zhang C, Fang F, Wang C. Progress of Translational Medicine in Alzheimer’s Disease. Front. Aging Neurosci. 2022, 14, 970044. Publisher’s Version

Pascoal TA, Chamoun M, Lax E, Wey HY, Shin M, Ng KP, Kang MU, Mathotaarachchi S, Benedet AL, Therriault J, Lussier FZ, Schroeder FA, DuBois JM, Hightower BG, Gilbert TM, Zürcher NR, Wang C, Hopewell R, Chakravarty M, Savard M, Thomas E, Mohaddes S, Farzin S, Salaciak A, Tullo S, Cuello AC, Soucy JP, Massarweh G, Hwang H, Kobayashi E, Hyman BT, Dickerson BC, Guiot MC, Szyf M, Gauthier S, Hooker JM, Rosa-Neto P. [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease. Nature Communications. 2022, 13, Article number: 4171. Publisher’s Version

Bai P, Yan L, Bagdasarian FA, Wilks MQ, Wey HY, Wang C. A Positron Emission Tomography Imaging Probe Selectively Targeting BD1 of Bromodomain and Extra-terminal Domain. Chemical Communications, 2022, 58, 9654-9657. Publisher’s Version

Sang Z, Bai P, Ban Y, Wang K, Wu A, Mi J, Hu J, Xu R, Zhu G, Wang J, Zhang J, Wang C, Tan Z, Tang L. Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer’s agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies. Bioorg Chem. 2022.127:106007. Publisher’s Version

Watson PR, Bai P, Wang C, Cragin AD, Hooker JM, Christianson DW. Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6. Biochemistry. 2022, 61(18):1945-1954. Publisher’s Version

Bai P, Mondal P, Bagdasarian FA, Rani N, Liu Y, Gomm A, Tocci DR, Choi SH, Wey HY, Tanzi RE, Zhang C, Wang C. Development of a potential PET probe for HDAC6 imaging in Alzheimer’s disease. Acta Pharm Sin B. 2022,12(10):3891-3904. Publisher’s Version

2021

Chen Z, Wang X, Yang X, Xu Y, Yang Y, Wang H, Li T, Bai P, Yuan G, Chen H, Yang J, Fiedler SA, Striar R, Bernales DR, Koegel RE, Cao Q, Ran C, Xiang B, Li H, Wang C. “Imaging assisted evaluation of antitumor efficacy of a new histone deacetylase inhibitor in the castration-resistant prostate cancer.” Eur J Nucl Med Mol Imaging. 2021, 48, 53-66. Publisher’s Version

 Bai P, Lan Y, Wang H, Chen Z, Fiedler SA, Striar R, Lu X, Wang C. “Development of a Novel Positron Emission Tomography (PET) Radiotracer Targeting Bromodomain and Extra-Terminal Domain (BET) Family Proteins.” Mol. Biosci. 2020, 7, 198. Publisher’s Version

Cahill CM, Aleyadeh R, Gao J, Wang C, Rogers JT. “Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson’s Disease and Potential Therapeutic Role of 5′ Untranslated Region-Directed Small Molecules.” Biomolecules. 2020, 10, 1465. Publisher’s Version

Wang H, Lan Y, Bai P, Chen Z, Luo S, Xu Y, Fiedler SA, Striar R, Wang C. “Radiosynthesis of [¹¹C]EI1 for imaging EZH2 using positron emission tomography.” Medicinal Chemistry Research. 2020, 29, 2106–2111. Publisher’s Version

Guo S, Wu K, Li C, Wang H, Sun Z, Xi D, Zhang S, Ding W, Zaghloul ME, Wang C, Castro FA, Yang D, Zhao Y. “Integrated contact lens sensor system based on multifunctional ultrathin MoS2 transistors.” Matter, 2020, 4, 969-985. Publisher’s Version

Ding W, You Z, Chen Q, Yang L, Doheny J, Zhou X, Li N, Wang S, Hu K, Chen L, Xia S, Wu X, Wang C, Zhang C, Chen L, Ritchie C, Huang P, Mao J, Shen S. “Gut Microbiota Influences Neuropathic Pain Through Modulating Proinflammatory and Anti-inflammatory T Cells.” Anesth Analg, 2021, 132:1146-1155. Publisher’s Version

Xu Y, Wang Y, Wang H, Wang C. “Synthesis and Characterization of Carbon-11 Labeled Iloperidone for Imaging of α 1-Adrenoceptor in Brain.” Front Mol Biosci. 2020, 7, 586327. Publisher’s Version

Xu Y, Xu Y, Blevins H, Lan Y, Liu Y, Yuan G, R Striar, Zagaroli Js, Tocci DR, Langan AG, Zhang C, Zhang S, Wang C. “Discovery of carbon-11 labeled sulfonamide derivative: A PET tracer for imaging brain NLRP3 inflammasome.” Bioorganic & Medicinal Chemistry Letters. 2021, 34, 127777. Publisher’s Version

Bai P, Lu X, Liu Y, Lan Y, Wang H, Fiedler SA, Striar R, Wang C. “Discovery of a Positron Emission Tomography Radiotracer Selectively Targeting the BD1 Bromodomains of BET Proteins.” ACS Medicinal Chemistry Letters. 2021, 12,282-287. Publisher’s Version

Chen S, Yu S, Du Z, Huang X, He M, Long S, Liu J, Lan Y, Yang D, Wang H, Li S, Chen A, Hao Y, Su Y, Wang C, Luo S. “Synthesis of Mitochondria-anchored Nitroimidazoles with a Versatile NIR Fluorophore for Hypoxic Tumor Targeting Imaging and Chemoradiotherapy.” Journal of Medicinal Chemistry. 2021, 64, 3381–3391. Publisher’s Version

Xu Y, Chen Z, Wey H-Y, Liang Y, Tanzi RE, Zhang C, Wang C. “Molecular imaging of NAD+-dependent deacetylase SIRT1 in the brain.” Alzheimer’s & Dementia. 2021,17(12):1988-1997. Publisher’s Version

Bai P, Lan Y, Wang H, Liu Y, Striar R, Yuan G, Afshar S, Zagaroli JS, Tocci DR, Langan AG, Wang C. “Synthesis and Characterization of a Positron Emission Tomography Imaging Probe Selectively Targeting the Second Bromodomain of Bromodomain Protein BRD4.” Bioconjug Chem. 2021;32(8):1711-1718. Publisher’s Version

Bai P, Lan Y, Patnaik D, Wang H, Liu Y, Chen Z, Yuan G, Afshar S, Striar R, Zagaroli JS, Tocci DR, Langan AG, Haggarty SJ, Wang C. “Design, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins.” J Med Chem. 2021, 64(19):14745-14756. Publisher’s Version

Lan Y, Bai P, Liu Y, Afshar S, Striar R, Rattray AK, Meyer TN, Langan AG, Posner AM, Shen S, Tanzi RE, Zhang C, Wang C. “Visualization of Receptor-Interacting Protein Kinase 1 (RIPK1) by Brain Imaging with Positron Emission Tomography.” J Med Chem. 2021, 64(20):15420-15428. Publisher’s Version

Xu Y, Xu Y, Biby S, Bai P, Liu Y, Zhang C, Wang C, Zhang S. “Novel Positron Emission Tomography Radiotracers for Imaging Mitochondrial Complex I.” ACS Chem Neurosci. 2021, 12(24):4491-4499. Publisher’s Version

2020

Yiwei Zhu, Stephanie A. Fiedler, Matthew L. Hibert, and Changning Wang. 2020. “Synthesis of a carbon-11 radiolabeled BACE1 inhibitor.” Medicinal Chemistry Research. Publisher’s Version

Bai P, Bai S, Lu X, Fiedler SA, Ntaganda B, Wey HY, Wang C. “A New Positron Emission Tomography Probe for Orexin Receptors Neuroimaging.” Molecules. 2020, 25,1018. Publisher’s Version

Sang Z, Wang K, Bai P, Wu A, Shi J, Liu W, Zhu G, Wang Y, Lan Y, Chen Z, Zhao Y, Qiao Z, Wang C, Tan Z. “Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer’s disease.” European Journal of Medicinal Chemistry. 2020, 194, 112265. Publisher’s Version

Bai P, Lu X, Lan Y, Chen Z, Patnaik D, Fiedler SA, Striar R, Haggarty SJ, Wang C. “Radiosynthesis and in vivo evaluation of a new positron emission tomography radiotracer targeting bromodomain and extra-terminal domain (BET) family proteins.” Nuclear Medicine and Biology, 2020, 84-85, 96-101. Publisher’s Version

Xu Y, Wang C, Wey HY, Liang Y, Chen Z, Choi SH, Ran C, Rynearson KD, Bernales DR, Koegel RE, Fiedler SA, Striar R, Wagner SL, Tanzi R, Zhang C. “Molecular imaging of Alzheimer’s disease-related gamma-secretase.” Journal of Experimental Medicine. 2020, 217, e20182266. Publisher’s Version

Tseng CJ, Gilbert TM, Catanese MC, Hightower BG, Peters AT, Parmar AJ, Kim M, Wang C, Roffman JL, Brown HE, Perlis RH, Zürcher NR, Hooker JM. “In vivo human brain expression of histone deacetylases in bipolar disorder.” Translational Psychiatry. 2020, 10, Article number: 224. Publisher’s Version

2019

Yu Lan, Ping Bai, Zude Chen, Ramesh Neelamegam, Michael S. Placzek, Hao Wang, Stephanie A. Fiedler, Jing Yang, Gengyang Yuan, Xiying Qu, Hayden R. Schmidt, Jinchun Song, Marc D. Normandin, Chongzhao Ran, and Changning Wang. 2019. “Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET).” Acta Pharmaceutica Sinica B, 9, 6, Pp. 1204-1215. Publisher’s Version

Yu Lan, Ping Bai, Zude Chen, Ramesh Neelamegam, Michael S. Placzek, Hao Wang, Stephanie A. Fiedler, Jing Yang, Gengyang Yuan, Xiying Qu, Hayden R. Schmidt, Jinchun Song, Marc D. Normandin, Chongzhao Ran, and Changning Wang. 2019. “Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET).” Acta Pharmaceutica Sinica B, 9, 6, Pp. 1204-1215. Publisher’s Version

Dong Yang, Hao Wang, Shenglin Luo, Changning Wang, Sheng Zhang, and Shiqi Guo. 2019. “Paper-Cut Flexible Multifunctional Electronics Using MoS2 Nanosheet.” Nanomaterials, 9, 7, Pp. 922. Publisher’s Version

Tonya M. Gilbert, Nicole R. Zürcher, Christine J. Wu, Anisha Bhanot, Baileigh G. Hightower, Minhae Kim, Daniel S. Albrecht, Hsiao-Ying Wey, Frederick A. Schroeder, Anais Rodriguez-Thompson, Thomas M. Morin, Kamber L. Hart, Amelia M. Pellegrini, Misha M. Riley, Changning Wang, Steven M. Stufflebeam, Stephen J. Haggarty, Daphne J. Holt, Marco L. Loggia, Roy H. Perlis, Hannah E. Brown, Joshua L. Roffman, and Jacob M. Hooker. 2019. “PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.” The Journal of Clinical Investigation, 129, 1, Pp. 364-372. Publisher’s VersionAbstract

Ping Bai, Hsiao-Ying Wey, Debasis Patnaik, Xiaoxia Lu, Yu Lan, Johanna Rokka, Fiedler Stephanie, Stephen J. Haggarty, and Changning Wang. 2019. “Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging.” Chemical Communications, 55, 86, Pp. 12932-12935. Publisher’s Version

Zude Chen, Xiashuang Wang, Yulong Xu, and Changning Wang. 2019. “Synthesis of 11C-labeled DNA polymerase-β inhibitor 5-methoxyflavone and PET/CT imaging thereof.” Nuclear Medicine and Biology, 78-79, Pp. 17-22. Publisher’s Version

Michael S. Placzek, Frederick A. Schroeder, Tao Che, Hsiao-Ying Wey, Ramesh Neelamegam, Changning Wang, Bryan L. Roth, and Jacob Hooker. 2019. “Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging.” ACS Chem. Neurosci., 10, Pp. 1384-395. Publisher’s Version

Tonya M. Gilbert, Nicole R. Zürcher, Mary C. Catanese, Chieh-En J. Tseng, Maria A. Di Biase, Amanda E. Lyall, Baileigh G. Hightower, Anjali J. Parmar, Anisha Bhanot, Christine J. Wu, Matthew L. Hibert, Minhae Kim, Umar Mahmood, Steven M. Stufflebeam, Frederick A. Schroeder, Changning Wang, Joshua L. Roffman, Daphne J. Holt, Douglas N. Greve, Ofer Pasternak, Marek Kubicki, Hsiao-Ying Wey, and Jacob M. Hooker. 2019. “Neuroepigenetic signatures of age and sex in the living human brain.” Nature Communications, 10, 2945. Publisher’s Version

2018

Hsiao-Ying Wey, Tonya M. Gilbert, Nicole R. Zürcher, Angela She, Anisha Bhanot, Brendan D. Taillon, Fredrick A. Schroeder, Changning Wang, Stephen J. Haggarty, and Jacob M. Hooker*. 2016. “Insights into neuroepigenetics through human histone deacetylase PET imaging.” Science Translational Medicine. , 8, 351, Pp. 351ra106. Publisher’s Version

Hsiao-Ying Wey*, Changning Wang, Frederick A. Schroeder, Jean Logan, Julie C. Price, and Jacob M. Hooker*. 2015. “Kinetic Analysis and Quantification of [11C]Martinostat for in Vivo HDAC Imaging of the Brain. .” ACS Chem Neurosci. , 6, 5, Pp. 708–715. Publisher’s Version

Ramesh Neelamegam, Tim Hellenbrand, Frederick A. Schroeder, Changning Wang, and Jacob M. Hooker*. 2014. “Imaging evaluation of 5-HT2C agonists, [11C]WAY-163909 and [11C]vabicaserin, formed by Pictet-Spengler cyclization. .” J Med Chem. , 57, 4, Pp. 1488–1494. Publisher’s Version

Changning Wang, Frederick A. Schroeder, Hsiao-Ying Wey, Ronald Borra, Florence F. Wagner, Surya Reis, Sungwon Kim, Edward B. Holson, Stephen J. Haggarty, and Jacob M. Hooker*. 2014. “In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. .” J Med Chem. , 57, 19, Pp. 7999–8009. Publisher’s Version

F. A. Schroeder, C. Wang, G. C. Van de Bittner, R. Neelamegam, W. R. Takakura, A. Karunakaran, H. Y. Wey, S. A. Reis, J. Gale, Y. L. Zhang, E. B. Holson, S. J. Haggarty, and J. M. Hooker*. 2014. “PET imaging demonstrates HDAC target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat. .” ACS Chem Neurosci. , 5, 10, Pp. 1055–1062. Publisher’s Version

C. Wang, F. A. Schroeder, and J. M. Hooker*. 2014. “Visualizing epigenetics: Current advances and advantages in HDAC PET imaging techniques. .” Neuroscience. , 264, Pp. 186–197. Publisher’s Version

Changning Wang, Christian K. Moseley, Stephen M. Carlin, Colin M. Wilson, Ramesh Neelamegam, and Jacob M. Hooker*. 2013. “Radiosynthesis and Evaluation of [11C]EMPA as a potential PET Tracer for Orexin 2 Receptors. .” Bioorg Med Chem Lett., 23, 11, Pp. 3389–3392. Publisher’s Version

Changning Wang, Chunying Wu, Daniela C. Popescu, Junqing Zhu, Wendy B. Macklin, Robert H. Miller, and Yanming Wang*. 2011. “Longitudinal Near Infrared Imaging of Myelination. .” J Neuroscience., 31, 7, Pp. 2382-2390. Publisher’s Version

Luca Frullano, Changning Wang, Robert H. Miller, and Yanming Wang*. 2011. “A Myelin-Specific Contrast Agent for Magnetic Resonance Imaging of Myelination. .” J Am Chem Soc. , 133, 6, Pp. 1611–1613. Publisher’s Version

Chunying Wu, Zhe Tang, Weiwen Fan, Wenxia Zhu, Changning Wang, Edurado Somoza, Norbert Owino, Ruoshi Li, Patrick C. Ma, and Yanming Wang*. 2010. “In Vivo Positron Emission Tomography (PET) Imaging of Mesenchymal−Epithelial Transition (MET) Receptor.” J. Med. Chem., 53, 1, Pp. 139-146. Publisher’s Version

Chunying Wu, Changning Wang, Daniela C. Popescu, Wenxia Zhu, Eduardo A. Somoza, Junqing Zhu, Allison G. Condie, Christopher A. Flask, Robert H. Miller, Wendy Macklin, and Yanming Wang*. 2010. “A Novel PET Marker for In Vivo Quantification of Myelination. .” Bioorg Med Chem. , 18, 24, Pp. 8592–8599. Publisher’s Version

Changning Wang, Haisheng Wang, Xuefei Huang, Li-He Zhang, and Xin-Shan Ye*. 2006. “Benzenesulfinyl Morpholine: a New Promoter for One-Pot Oligosaccharide Synthesis Using Thioglycosides by Pre-Activation Strategy.” Synlett, 17, Pp. 2846-2850. Publisher’s Version